1993

• Langer & Vacanti

  Introduction of the concept of "tissue engineering" in the literature.

  

1994

1995

1996

1997

• Howell et al

  First clinical trial of PDGF/IGF-1 in hydogel vehicle for periodontal regeneration in human.

  

1997

• Heijl et al

  RCT evaluating the use of EMD in hydrogel carrier for periodontal regeneration.

  

1998

• Yukna et al

  RCT evaluating the use of a synthetic cell-binding peptide (P-15) with xenogenic bone graft for periodontal regeneration.

  

1999

2000

• Bartold et al

  Seminal review introducing concept of tissue engineering for periodontal regeneration.

  

2000

• van der Bergh et al

  Case series applying OP-1 in a collagen carrier for sinus floor augmentation procedures.

  

2001

2002

2003

• Nevins et al

  First report of periodontal regeneration of class II furcation defects using an allogenic bone graft substitute saturated with rhPDGF-BB.

  

2003

• Pini-Prato et al

  Case series of gingival augmentation procedures using an autogenous hyaluronic acid-enriched cell graft.

  

2003

• Wiltfang et al

  RCT evaluating the use of PRP with alloplastic bone graft substitute for sinus floor augmentation procedures.

  

2004

• Seo et al

  First identification and characterization of periodontal ligament stem cells in human teeth.

  

2005

• Boyne et al

  RCT evaluating the effect of rhBMP-2 delivered in a collagen sponge for maxillary sinus floor augmentation.

  

2005

• Fiorellini et al

  RCT evaluating the use of rhBMP-2 in a collagen carrier for alveolar ridge reconstruction.

  

2005

• McGuire & Nunn

  RCT evaluating the performance of a living tissue-engineered human fibroblast-derived dermal substitute for keratinized tissue augmentation around teeth.

  

2005

• Nevins et al

  Multicenter RCT evaluating the use of rhPDGF-BB combined with an alloplastic bone graft substitute for periodontal regeneration.

  

2005

• Wilson Jr et al

  RCT evaluating a living tissue-engineered human fibroblast-derived dermal substitute for root coverage.

  

2006

2007

• Mohammadi et al

  RCT evaluating the use of a collagen scaffold containing cultured autogenous fibroblasts for gingival augmentation.

  

2008

2009

• d'Aquino et al

  First study reporting bone regeneration in humans following the application of a collagen sponge with dental pulp stem/progenitor cells.

  

2009

• Mangano et al

  Use of autogenous osteoblasts seeded on a polyglycolic-polylactic scaffold for sinus floor augmentation.

  

2010

• Feng et al

  Case series of periodontal regeneration using autologous periodontal ligament progenitor cells in an alloplastic bone substitute carrier.

  

2010

• Jhaveri et al

  Case series of root coverage procedures utilizing an acellular dermal matrix seeded with autologous gingival fibroblasts.

  

2011

• McGuire et al

  Multicenter RCT testing a collagen matrix seeded with allogeneic keratinocytes and dermal fibroblasts for enhancing keratinized tissue around teeth.

  

2011

• Nevins et al

  RCT evaluating the use of rhPDGF-BB or EMD with xenogenic bone graft substitute in alveolar ridge reconstruction.

  

2012

2013

• de Freitas et al

  RCT evaluating rhBMP-2 delivered in an absorbable collagen sponge carrier for horizontal ridge augmentation.

  

2013

• Froum et al

  RCT assessing rhPDGF in combination with a xenogenic bone graft substitute for sinus floor augmentation procedures.

  

2013

• Kaigler et al

  RCT evaluating the use of CD90+ stem cells and CD14+ monocytes applied to a gelatin sponge in alveolar ridge preservation.

  

2014

• Ivanovski et al

  Review of multiphasic scaffolds for compartmentalized tissue engineering to promote periodontal regeneration.

  

2015

• Kaigler et al

  RCT applying alloplastic bone graft substitute enriched with CD90+ stem cells and CD14+ monocytes for sinus augmentation procedures.

  

2015

• Rasperini et al

  First case report illustrating the use of 3D-printed scaffolds with rhPDGF-BB for periodontal reconstruction.

  

2015

• Santana & Santana

  RCT assessing an alloplastic bone graft substitute combined with rhPDGF-BB for horizontal bone augmentation.

  

2016

• Chen et al

  RCT applying a xenogenic bone graft subtitute with autologous periodontal ligament stem cells for periodontal regeneration of intrabony defects.

  

2017

• Sangiorgio et al

  RCT evaluating the use of a collagen matrix with EMD for treating gingival recession.

  

2018

• Clark et al

  RCT evaluating the use of A-PRF with allogenic bone graft substitute for alveolar ridge preservation.

  

2018

• Ferrarotti et al

  RCT using a collagen sponge scaffold complexed with autogenous dental pulp micrografts for periodontal regeneration of deep intrabony defects.

  

2018

• Mercado et al

  Case series evaluating the use of EMD, xenogenic bone graft substitute, and doxycycline for the treatment of peri-implantitis.

  

2018

• Thoma et al

  RCT evaluating the use of xenogeneic bovine bone blocks loaded with rhBMP-2.

  

2019

2020

• Sanchez et al

  RCT evaluating autologous periodontal ligament-derived mesenchymal stem cells embedded in a xenogeneic bone substitute for the regenerative treatment of intra-bony periodontal defects.

  

2020

• Lee et al

  RCT evaluating the use of EMD with a collagenated xenogenic bone graft for alveolar ridge preservation.

  

2021

• Lin et al

  RCT evaluating the use of CGF with xenogenic bone graft in alveolar ridge preservation.

  

2022

• Jung et al

  Seventeen-year follow-up of an RCT testing rhBMP-2 combined with a xenogenic bone graft substitute for horizontal ridge augmentation.

  

2022

• Pilenza et al

  Case series evaluating the use of EMD and xenogenic bone graft substitute for the treatment of peri-implantitis.

  

2022

• Tavelli et al

  RCT evaluating the use of a cross-linked collagen matrix with rhPDGF-BB for the treatment of multiple gingival recessions.

  

2023

• Tavelli et al

  Thirteen-year follow-up of an RCT testing a collagen matrix seeded with allogeneic keratinocytes and dermal fibroblasts to enhance keratinized tissue around teeth.

  

2024

• Ivanovski et al

  Case report on the use of a 3D-printed patient-specific scaffold combined with iPRF with xenogenic bone graft substitute and autogenous bone graft horizontal ridge augmentation.

  

2024

• Ivanovski et al

  Contemporary review of clinical trials using dental mesenchymal stem cells.